Name
ICD-O-1 Morphology
Effective 1978 - 1991
ICD-O-2 Morphology
Effective 1992 - 2000
ICD-O-3 Morphology
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
See Module 3: Rules PH5, PH6
Most common sites of involvement: bone marrow, peripheral blood, lymph nodes
Help me code for diagnosis year :
Abstractor Notes
Diagnostic Confirmation
This histology can be determined by positive histology (including peripheral blood) with or without genetics and/or immunophenotyping. Review the Definitive Diagnostic Methods, Immunophenotyping and Genetics Data sections below, and the instructions in the Hematopoietic Manual for further guidance on assigning Diagnostic confirmation.
Module Rule
Alternate Names
All variants of BCLL
CLL/SLL
SLL
SLL/CLL
Definition
Definitive Diagnostic Methods
FISH
Flow cytometry
Genetic testing
Histologic confirmation
Immunophenotyping
Genetics Data
Immunophenotyping
CD5+
CD10-
CD11c
CD19 expressed
CD20 expressed
CD22 expressed
CD23+
CD43+
CD79A
CD79b expressed
CD200+
Cyclin D1 not expressed
FMC7 negative or weakly expressed
LEF1 aberrantly expressed
Weak or dim surface IgM/IgD
Treatments
Chemotherapy
Hormone therapy
Immunotherapy
Transformations to
Transformations from
None
Same Primaries
Corresponding ICD-9 Codes
204.1 Chronic lymphoid leukemia (CLL)
Corresponding ICD-10 Codes
C91.1 Chronic lymphocytic leukemia (CLL)
Corresponding ICD-10-CM Codes (U.S. only)
C91.1 Chronic lymphocytic leukemia of B-cell type (CLL) (effective October 01, 2015)
Signs and Symptoms
Extranodal infiltrates
Fatigue
Hepatomegaly
Infections
Lymphadenopathy
Splenomegaly
Diagnostic Exams
Flow cytometry
Immunohistochemistry
Immunophenotyping
Progression and Transformation
2-8% of CLL patients transform to DLBCL
<1% of CLL patients develop classical Hodgkin lymphoma
Epidemiology and Mortality
Age: 65 years median age (diagnosis in younger adults increasing)
Incidence: 2-6 cases per 100,000 per person per year (most common leukemia in adults in Western countries)
Race: slight female predominance
Sources
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 216-220
International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages:
//www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
National Cancer Institute
Section: General Information About Adult Non-Hodgkin Lymphoma (NHL)
Pages: //www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq
Leukemia, Lymphocytic, Chronic, B-Cell D015451
1 indication for 561 drugs (206 approved, 355 experimental)
Diseases [C] » Pathological Conditions, Signs and Symptoms [C23] » Pathologic Processes » Disease Attributes » Chronic Disease » Leukemia, Lymphocytic, Chronic, B-Cell
Diseases [C] » Neoplasms [C04] » Neoplasms by Histologic Type » Leukemia » Leukemia, Lymphoid » Leukemia, B-Cell » Leukemia, Lymphocytic, Chronic, B-Cell
Diseases [C] » Hemic and Lymphatic Diseases [C15] » Lymphatic Diseases » Lymphoproliferative Disorders » Leukemia, Lymphoid » Leukemia, B-Cell » Leukemia, Lymphocytic, Chronic, B-Cell
Diseases [C] » Immune System Diseases [C20] » Immunoproliferative Disorders » Lymphoproliferative Disorders » Leukemia, Lymphoid » Leukemia, B-Cell » Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease. MeSH