Fluticasone propionate
Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a steroid medication.[6] When inhaled it is used for the long term management of asthma and COPD.[6] In the nose it is used for hay fever and nasal polyps.[7][8] It can also be used for mouth ulcers.[9] Common side effects when inhaled include upper respiratory tract infections, sinusitis, thrush, and cough.[6] Common side effects when used in the nose include nosebleeding and sore throat.[7] It works by decreasing inflammation.[6] Fluticasone propionate was patented in 1980, and approved for medical use in 1990.[10] It is available as a generic medication.[8] In 2020, fluticasone was the 23rd most commonly prescribed medication in the United States, with more than 24 million prescriptions.[11][12] Medical uses[edit]Fluticasone propionate is used by powder or aerosol inhalation for the prophylaxis of asthma.[3][6] The nasal spray is used for prevention and treatment of allergic rhinitis.[2] Nasal drops are used in the treatment of nasal polyps. The nasal spray can also be used in the mouth for mouth ulcers.[9] Fluticasone propionate in a topical form can be used to treat skin conditions such as eczema, psoriasis, and rashes.[13] Adverse effects[edit]If taken correctly, the nasal spray and oral inhaler formulation have fewer corticosteroid side effects than the tablet formulation because they limit systemic (blood) absorption.[2] However, systemic absorption is not negligible even with correct administration.[2] Using the spray or inhaler at higher than recommended doses or with other corticosteroids can increase the risk for serious, systemic corticosteroid induced side effects.[2][3] These side effects include weakened immune system, increased risk of systemic infections, osteoporosis, and elevated pressure in the eyes.[14] Nasal spray[edit] Common side effects may include nasal irritation (burning, stinging, bleeding), headache, upset stomach (nausea, vomiting), and diarrhea. Rare side effects include infection (evidenced by, for example, fever, sore throat, and cough), vision problems, severe swelling, hoarse voice, and difficulty breathing or swallowing.[15][7][2] Inhaled[edit]Common side effects may include upper respiratory tract infection, throat irritation, thrush, cough, and headache. Rare side effects include bruising, swelling of the face/neck, depression, tiredness, and shortness of breath.[16][6][3] Pharmacology[edit]Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen, estrogen, or mineralocorticoid receptors,[4] thereby producing anti-inflammatory and vasoconstriction effects. It has been shown to have a wide range of inhibitory effects on multiple cell types (e.g. mast cell, eosinophil, neutrophil, macrophages, and lymphocytes) and mediators (e.g. histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation. Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, due to its low systemic bioavailability. Interactions[edit]Fluticasone propionate is broken down by CYP3A4 (Cytochrome P450 3A4), and has been shown to interact with strong CYP3A4 inhibitors such as ritonavir and ketoconazole.[2][3] Ritonavir is a common drug used in the treatment of HIV. Coadministration of ritonavir and fluticasone may lead to increased levels of fluticasone in the body, which may lead to Cushing's Syndrome and adrenal insufficiency.[17] Ketoconazole, an antifungal drug, has also been shown to increase fluticasone concentration leading to systemic corticosteroid side effects.[2][3] See also[edit]
References[edit]
External links[edit]
Is it better to take FLONASE at night or in the morning?Is it better to use FLONASE at night? In short, no. One daily dose of FLONASE Allergy Relief delivers 24-hour relief from your worst allergy symptoms. So, even if you take it in the morning, you're still covered for all night long, without pesky allergy symptoms.
Will fluticasone propionate unclog my nose?Fluticasone nasal spray is usually used to treat symptoms such as congestion, sneezing, and runny nose caused by seasonal or year-round allergies. The spray is usually used long term on a regular basis.
What is the best time of day to use fluticasone?Fluticasone propionate: Adults—At first, 2 sprays in each nostril once a day. Some patients may need 1 spray in each nostril two times a day (morning and evening). Your doctor may adjust your dose as needed.
How often should you use fluticasone propionate nasal spray?Fluticasone propionate: Adults—At first, 2 sprays in each nostril once a day. Some patients may need 1 spray in each nostril two times a day (morning and evening). Your doctor may adjust your dose as needed.
|
How long does it take for fluticasone propionate to work
Related Posts
Copyright © 2024 chuyencu Inc.
