Lymphoma & related disordersHodgkin lymphomaNodular lymphocyte predominant Show Last author update: 11 October 2019 Last staff update: 23 August 2022 Copyright: 2002-2022, PathologyOutlines.com, Inc. PubMed Search: Nodular lymphocyte predominant Hodgkin lymphoma Page views in 2021: 26,834 Page views in 2022 to date: 23,579 Cite this page: Balakrishna J, Jaffe ES. Nodular lymphocyte predominant. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphomanonbnlphl.html. Accessed November 14th, 2022. Definition / general
Essential features
Terminology
ICD coding
Epidemiology
Sites
Pathophysiology
Etiology
Clinical features
Diagnosis
Prognostic factors
Case reports
Treatment
Gross description
Microscopic (histologic) description
Microscopic (histologic) images Contributed by Elaine S. Jaffe, M.D., Jayalakshmi Balakrishna, M.D. and Lauren B. Smith, M.D.
Vaguely nodular architecture
Rare large neoplastic cells
LP cells or popcorn cells
Neoplastic cells positive for CD20
T cell rich variant with rare small B cells in the background
Neoplastic cells positive for CD20
OCT2 stain is helpful in highlighting the neoplastic cells
Neoplastic cells positive for PAX5
Neoplastic cells positive for BCL6
IgD expressing LP cells
T cell rosettes around LP cells
CD4 T cells predominate in the background
T cells express PD-1
PD-1 positive T cells form rosettes around LP cells
Expanded follicular dendritic cell meshwork
Effaced lymph node architecture
Lymphocyte predominant cell (LP cell / popcorn cell)
LP cells express CD20 Positive stains
Negative stains
Molecular / cytogenetics description
Sample pathology report
Differential diagnosis
Board review style question #1
A 20 year old man presents with an enlarged painless cervical lymph node he has had for the past 6 months. An excisional biopsy is shown in the image. The neoplastic cells are positive for CD45 and CD20 and are negative for CD15 and CD30. Which of the following is true about this entity?
Board review style answer #1 Board review style question #2 What is the immunophenotype of T cells in the microenvironment of nodular lymphocyte predominant Hodgkin lymphoma?
Board review style answer #2 Back to top What is the ICD
What is nodular lymphocyte predominant Hodgkin lymphoma?Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare type of lymphatic cancer. It occurs when lymphocytes, a type of white blood cell in your immune system, behave abnormally. Specifically, NLPHL occurs in B lymphocytes. There are different types of lymphoma: Hodgkin or non-Hodgkin.
What is nodular lymphocyte predominant HL?What is NLPHL? Nodular lymphocyte-predominant Hodgkin lymphoma is an uncommon type of Hodgkin lymphoma – a type of cancer that starts in the lymphatic system. The lymphatic system is part of the immune system. It is a network of glands (lymph nodes) and tubes that carry a fluid called lymph around the body.
How is nodular lymphocyte predominant Hodgkin treated?First-line treatment of stage IA NLPHL usually consists of limited-field radiotherapy alone. Patients with early-stage NLPHL other than stage IA and intermediate-stage disease mostly receive combined-modality treatment, whereas individuals with advanced NLPHL are treated with chemotherapy alone.
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